A majority could well imagine undergoing psychotherapy via artificial intelligence, among other things because of the ability to comfortably talk about embarrassing experiences

Attitudes and perspectives towards the preferences for artificial intelligence in psychotherapy. Mehmet Emin Aktan, Zeynep Turhan, İlknur Dolu. Computers in Human Behavior, March 29 2022, 107273. https://doi.org/10.1016/j.chb.2022.107273

Highlights

• We explored the factors of choosing AI-based psychotherapy.

• The less stigma and remote access were found as key in preferring AI-based therapy.

• Trust of the security of data in AI-based therapy were less than human therapists.

• The beliefs about limited ability to empathize in AI-based psychotherapy was found.

Abstract: The use of artificial intelligence (AI) in psychotherapy has been increased in recent years. While these technologies in psychotherapy are growing, the circumstances of accepting artificial tools during psychotherapy need to be explored to improve effective AI tools during the sensitive therapeutic environment. In this study, the factors around the preferences for AI-based psychotherapy were investigated. This cross-sectional study was conducted with a sample of 872 individuals who are highly educated, 18 aged and above. Attitude towards AI-based Psychotherapy, Attitude towards Seeking Professional Psychological Help Scale- Short Form, and Stigma Scale for Receiving Psychological Help Scale were used to examine the factors of participants' preferences for AI-based psychotherapy. While 55% of the sample preferred AI-based psychotherapy, the majority of participants trusted more human psychotherapists than AI-based systems when asked participants’ trust about the security of personal data. However, three important benefits of AI-based psychotherapy were identified as being able to comfortably talk about the embarrassing experiences, having accessibility at any time, and accessing remote communication. Importantly, factors of preferences for AI-based psychotherapy were related to the idea of AI-based psychotherapy systems can improve themselves based on the results from previous therapeutic experiences. Gender and the types of profession related to psychology and technical/engineering were also associated with choosing AI-based psychotherapy. The results suggest that both raising awareness of the benefits and effectiveness of psychotherapy as well as the trust to the artificial intelligence tools can improve the rate of the preferences for AI-based psychotherapy.

Keywords: Artificial intelligencePsychotherapyAccessibilityHelp-seeking behaviorStigma

Serial Sexual Murderers: Criminal paraphilia developed to reinforce positive emotions from sexual fantasies and helped to create a sense of intimacy to avoid being rejected

The Role of Child and Adult Sexual Fantasies and Criminal Paraphilia Involving Serial Sexual Murderers. Heather Brown. Walden University, PhD Dissertation. Mar 2022. https://www.proquest.com/openview/9bca3a21831039db7a1412f44af51536/1?pq-origsite=gscholar&cbl=18750&diss=y

Abstract: Childhood trauma may be a reason a child develops maladaptive coping mechanisms such as sexual fantasies and paraphilia. These coping mechanisms increase in intensity, leading to sexual violence to gain a sense of power and control. Even though researchers have identified that serial sexual killers suffer from child and adult sexual fantasies and criminal paraphilia, details of the sexual fantasies and paraphilia have not been examined. The purpose of this qualitative exploratory case study was to explore the role of child and adult sexual fantasies and criminal paraphilia involving serial sexual murderers. Hickey’s trauma-control model and relational paraphilic attachment theory were used as the theoretical foundations. Data were collected from 12 U.S. male participants identified as serial sexual murderers. Four themes were identified from the thematic analysis and were linked to all 12 case participants. Findings indicated child and adult sexual fantasies began as a maladaptive coping mechanism to avoid feeling abandoned, which escalated to ways of feeling control and revenge. Criminal paraphilia developed to reinforce positive emotions from sexual fantasies and helped to create a sense of intimacy to avoid being rejected. Findings may assist law enforcement, school staff, and mental health professionals to promote positive social change by preventing future risk for behaviors that lead to and are incorporated into the sexual murders committed by serial killers.

Men and women invested equally in improving their appearance if exercising and bodybuilding were included

Sex Differences in Physical Attractiveness Investments: Overlooked Side of Masculinity. Marta Kowal. Int. J. Environ. Res. Public Health 2022, 19(7), 3842; Mar 24 2022. https://doi.org/10.3390/ijerph19073842

Abstract

Background: Public opinion on who performs more beauty-enhancing behaviors (men or women) seems unanimous. Women are often depicted as primarily interested in how they look, opposed to men, who are presumably less focused on their appearance. However, previous studies might have overlooked how masculinity relates to self-modification among men. Methods: We explored this issue in depth by conducting a qualitative Study 1 aimed to establish how men and women enhance their attractiveness (N = 121) and a quantitative Study 2 aimed to test time spent on activities that increase one’s attractiveness in a longitudinal design (with seven repeated measures from 62 participants; N(total) = 367). Results: We observed no sex differences in beauty investments. Although women spent more time on make-up and cosmetics usage, men caught up with women in exercising and bodybuilding. Conclusion: Our study provides evidence that there may not be such wide sex differences in the intensity of enhancing one’s appearance as has been previously thought. We hypothesize that this might partly stem from changes in gender roles regarding masculinity.

Keywords: gender; diary study; enhancing beauty; self-modification; sex comparison

The cat parasite Toxoplasma gondii might boost people's sexual attractiveness, possibly thru changes in facial symmetry

Borraz-León JI, Rantala MJ, Krams IA, Cerda-Molina AL, Contreras-Garduño J. 2022. Are Toxoplasma-infected subjects more attractive, symmetrical, or healthier than non-infected ones? Evidence from subjective and objective measurements. PeerJ 10:e13122. Mar 2022. https://doi.org/10.7717/peerj.13122

Abstract

Background: Parasites are among the main factors that negatively impact the health and reproductive success of organisms. However, if parasites diminish a host’s health and attractiveness to such an extent that finding a mate becomes almost impossible, the parasite would decrease its odds of reproducing and passing to the next generation. There is evidence that Toxoplasma gondii (T. gondii) manipulates phenotypic characteristics of its intermediate hosts to increase its spread. However, whether T. gondii manipulates phenotypic characteristics in humans remains poorly studied. Therefore, the present research had two main aims: (1) To compare traits associated with health and parasite resistance in Toxoplasma-infected and non-infected subjects. (2) To investigate whether other people perceive differences in attractiveness and health between Toxoplasma-infected and non-infected subjects of both sexes.

Methods: For the first aim, Toxoplasma-infected (n = 35) and non-infected subjects (n = 178) were compared for self-perceived attractiveness, number of sexual partners, number of minor ailments, body mass index, mate value, handgrip strength, facial fluctuating asymmetry, and facial width-to-height ratio. For the second aim, an independent group of 205 raters (59 men and 146 women) evaluated the attractiveness and perceived health of facial pictures of Toxoplasma-infected and non-infected subjects.

Results: First, we found that infected men had lower facial fluctuating asymmetry whereas infected women had lower body mass, lower body mass index, a tendency for lower facial fluctuating asymmetry, higher self-perceived attractiveness, and a higher number of sexual partners than non-infected ones. Then, we found that infected men and women were rated as more attractive and healthier than non-infected ones.

Conclusions: Our results suggest that some sexually transmitted parasites, such as T. gondii, may produce changes in the appearance and behavior of the human host, either as a by-product of the infection or as the result of the manipulation of the parasite to increase its spread to new hosts. Taken together, these results lay the foundation for future research on the manipulation of the human host by sexually transmitted pathogens and parasites.

Discussion

For the first hypothesis, we found that Toxoplasma-infected subjects had lower facial FA than non-infected ones. Broken out by sex, we found that Toxoplasma-infected men had lower facial FA than non-infected men, whereas Toxoplasma-infected women had lower body mass, lower BMI, and a tendency to lower facial FA, higher self-perceived attractiveness, and a higher number of sexual partners than non-infected ones. Previous studies have reported positive associations between symmetrical traits, health, good genes, attractiveness, and parasitic resistance both in humans and non-human animals (e.g., Møller, 1992; Gangestad, Thornhill & Yeo, 1994; Polak, 1997; Borráz-León et al., 2021b; Luoto et al., 2021). Thus, one possible explanation for our results is that highly symmetrical subjects can successfully afford the physiological costs related to parasitism, which supports the hypothesis that highly symmetrical features are honest signals of good health (Borráz-León, Cerda-Molina & Mayagoitia-Novales, 2017; Luoto et al., 2021, but see Pound et al., 2014). Another possibility is that T. gondii infection may produce changes in facial symmetry of its hosts through changes in endocrinological variables such as testosterone levels; this hypothesis is consistent with the finding that Toxoplasma-infected men have higher testosterone levels (Flegr, Lindová & Kodym, 2008; Borráz-León et al., 2021a) and Toxoplasma-infected women have lower testosterone levels than non-infected subjects (Flegr, Lindová & Kodym, 2008), as well as with some data showing that body symmetry can change due to hormonal fluctuations across the menstrual cycle (Scutt & Manning, 1996; but see Marcinkowska & Holzleitner, 2020). These changes, both in the endocrinology system and in facial symmetry, would ultimately benefit the spread of the parasite by increasing the attractiveness of its hosts through increasing their facial symmetry. This hypothesis is also consistent with previous results showing that Toxoplasma-infected male rats have higher testosterone levels and are preferred as sexual partners by non-infected females (Dass et al., 2011), and with positive relationships between high testosterone levels, attractiveness, and immune responses in men (Rantala et al., 2012; Luoto et al., 2021). However, this hypothesis must be empirically tested further since other studies have found no direct associations between testosterone levels and facial symmetry (e.g., Borráz-León et al., 2014).

Regarding the lower body mass and the lower BMI of Toxoplasma-infected women, it is important to highlight that the values of both physical measurements are within what is considered “normal” and healthy (Brown et al., 2016). These results support the view that T. gondii might also increase the metabolic rate of its hosts which would influence their health and attractiveness perceptions. The tendency for reporting higher self-perceptions of attractiveness and a higher number of sexual partners among Toxoplasma-infected women is consistent with this explanation since the acquisition of sexual partners through more active mate-seeking, short-term sociosexual orientation, and higher attractiveness would facilitate the spread of T. gondii to new hosts. Another possibility is that Toxoplasma-infected subjects from both sexes are showing more attractive characteristics as a terminal investment strategy (e.g., Fessler et al., 2005). Nevertheless, this hypothesis is less plausible since there were no significant age differences between Toxoplasma-infected and non-infected subjects.

Regarding the second hypothesis, we found that other-perceptions of attractiveness and health are higher for Toxoplasma-infected subjects than for non-infected ones, independent of their sex. Moreover, the BMI and pathogen disgust of raters modulated the attractiveness and health perceptions of infected and non-infected subjects indistinctly. Interestingly, there also was a tendency for raters who had lower pathogen disgust and higher self-rated health to evaluate the faces of Toxoplasma-infected subjects as healthier than the faces of non-infected ones. Likewise, those raters with lower sexual disgust also tended to evaluate Toxoplasma-infected subjects as more attractive than non-infected ones. These results support and extend previous literature showing that, for example, Toxoplasma-infected male rats are preferred as sexual partners by females (Dass et al., 2011). Thus, it is possible that the same effect reported for Toxoplasma-infected male rats is present in Toxoplasma-infected humans. This effect may be modulated by phenotypic characteristics of potential mates such as disgust sensitivity and self-perceived health (e.g., Park, van Leeuwen & Stephen, 2012).

At this point, it is important to highlight that even though between 30% and 80% of the global population may be infected with T. gondii (e.g., Flegr, 2007; Johnson & Johnson, 2020), with transmission routes including contact with cat feces, contaminated food or water, or sexual intercourse with an infected person (Flegr, 2007; Flegr & Horáček, 2019; Tong et al., 2021), only a meager percentage of subjects (mainly those who are immunosuppressed) may develop severe complications associated with the infection (Johnson & Johnson, 2020). Likewise, a low percentage of infected subjects may develop mental disorders such as schizophrenia, obsessive-compulsive disorder, or suicidal tendencies (Flegr & Horáček, 2019; Torrey & Yolken, 2019; Nayeri, Sarvi & Daryani, 2022). However, it seems that exposure to previous traumatic experiences, chronic stress, genetic predisposition, drugs abuse, as well as Toxoplasma and other pathogen infections (e.g., Cytomegalovirus, herpes, Clamydia spitacci, Treponema pallidum) are all involved in the development of these mental disorders (MJ Rantala et al., 2021, unpublished data). In immunocompetent subjects, Toxoplasma infection may cause mild disease and usually turns into life-long latent toxoplasmosis being clinically asymptomatic (Roberts et al., 2001). Therefore, it is possible that the apparently non-pathological and potentially beneficial interactions between T. gondii and some of its intermediate hosts, such as rats and humans are the result of co-evolutionary strategies that benefit, or at least do not harm, the fitness of both the parasite and the host.

Some examples of parasites that manipulate the appearance and behavior of their hosts to increases their attractiveness have been previously described in nature. For example, female moths of Helicoverpa zea infected with gonad-specific virus (GSV) or Hz-2V virus produce three to seven times more sex pheromone than non-infected females which could increase their sexual attractiveness (Burand et al., 2005). Likewise, water snails (Potamopyrugus antipodarum) infected with a trematode (Microphallus sp.) enhance their sexual attractiveness measured by an increase in the number of mating events and the total number of different mating partners (Soper et al., 2014). Even though reports about host manipulation by sexually transmitted pathogens and the potential benefits these pathogens could gain remain scarce in humans (e.g., Heil, 2016). The present study offers novel evidence supporting the idea that some sexually transmitted parasites such as T. gondii (e.g., Hlaváčová et al., 2020; Tong et al., 2021), may produce changes in the appearance and behavior of the human host, either as a by-product of the infection or as the result of the manipulation of the parasite to increase its spread to new hosts.

Limitations and future directions

The small sample size of the present study may have been an important limiting factor for finding statistical differences in the other studied phenotypic traits. Therefore, further studies with larger sample sizes must be carried out to confirm or reject the hypotheses tested in this study. Another limitation is that in the present study, physiological, immunological, and/or genetic markers associated with health were not directly measured. Although previous research has shown the advantages of using phenotypic over genotypic measurements of immune function and health (e.g., Luoto et al., 2021), future research must take the present limitations into account to offer a more complete explanation about how T. gondii may manipulate hosts’ behavior, morphology, and/or physiology.

Since reports that T. gondii can be a sexually transmitted parasite in humans are relatively recent (e.g., Flegr, Klapilová & Kaňková, 2014; Hlaváčová et al., 2020; Kaňková, Hlaváčová & Flegr, 2020; Tong et al., 2021), many questions and hypotheses still need to be properly formulated and tested in further studies. In this study, we provided the first evidence that Toxoplasma-infected individuals are more symmetrical and are perceived as more attractive and healthier than non-infected ones. Thus, further research can investigate, for example, the effect of Toxoplasma-status of raters on sociosexual orientation characteristics. It is possible that Toxoplasma-infected individuals may rate more positively the faces of potential mates which would benefit the spread of T. gondii by making them less choosy and probably exhibiting a short-term over a long-term sociosexual orientation. The effect of the menstrual cycle phase is another variable that have to be further studied. It could be possible that Toxoplasma-infected women who are in the fertile phase of the menstrual cycle, rate even more positively the faces of potential mates than Toxoplasma-infected women who are in other phase of the menstrual cycle, since changes in attractiveness perceptions during the menstrual cycle have been previously reported (e.g., Gangestad et al., 2007; Jones et al., 2008). Other future studies can look for differences in ejaculate quality between Toxoplasma-infected and non-infected men. Since T. gondii infection produces changes in testosterone levels, it is feasible that these changes may also affect some ejaculate parameters such as motility, sperm velocity, or ejaculate volume. In general, if the premises of the manipulation hypothesis by T. gondii are correct, such effects would increase its transmission rate to new hosts. Further research is also needed to study potential metabolic and physiological costs associated with Toxoplasma infection. For example, it is likely that the phenotypic changes of Toxoplasma-infected subjects such as lower facial FA, higher testosterone levels, and high-risk behaviors reported in this and other studies (Flegr, 2007; Johnson et al., 2018; Borráz-León et al., 2021a), may impose physiological costs to the host such as shortened life, reduced life quality during late adulthood, or increased predisposition to develop organic (e.g., hearth and pulmonary diseases) and mental diseases (e.g., depression, schizophrenia, bipolar disorder). Therefore, covariation between attractiveness, facial symmetry, changes in sex hormones and neurotransmitters, and the expression of physical and psychopathological symptoms, might be expected in genetically predisposed individuals. In the aggregate these research suggestions can shed light on the effects of Toxoplasma infection in human sociosexual and health domains.

Results showed that boys as young as age 3 generally valued strength more than girls: boys, on average, said it was more important to be strong than girls did, & were more likely to prefer strength-related occupations than girls

Early Gender Differences in Valuing Strength. May Ling D. Halim, Dylan J. Sakamoto, Lyric N. Russo, Kaelyn N. Echave, Miguel A. Portillo & Sachiko Tawa. Archives of Sexual Behavior, Mar 28 2022. https://link.springer.com/article/10.1007/s10508-021-02185-4

Abstract: Being strong is a prominent male stereotype that children learn early in life; however, it is unknown as to when children start to value being strong and when gender differences in valuing strength might emerge. In the current study, we interviewed an ethnically diverse sample of 168 3–5 year-olds (88 girls, 80 boys) to address this gap in the literature. Results showed that boys as young as age 3 generally valued strength more than girls: (1) boys, on average, said it was more important to be strong than girls did, and (2) boys were more likely to prefer strength-related occupations than girls. Boys were also more likely to select boys than girls as the gender who cares more about physical strength. Additionally, with age, both girls and boys demonstrated knowledge of the stereotype that boys care about physical strength, with girls also being less likely to associate being a girl with being strong. Overall, the results suggest that valuing physical strength starts in early childhood, and gender differences in valuing strength are evident at the eve of gender identity development. Possible implications for boys’ later well-being and health are discussed.

Individuals with higher income may exhibit profiles of adult personality development that more closely resemble aspects of a healthy personality

Income moderates changes in big-five personality traits across eighteen years. Vincent YS Oh, Ismaharif Ismail, Eddie MW Tong. European Journal of Personality, March 28, 2022. https://doi.org/10.1177/08902070221078479

Abstract: The role of income in adult personality change remains poorly understood. Using latent growth modeling, we performed exploratory analyses of how longitudinal trajectories of change in personal income and the Big Five personality traits would be related. We examined 4234 participants (2149 Males, 2085 Females; MT1age = 46.42, SDT1age = 13.36, age range at T1: 20–74 years) across three time points spanning 18 years using data from the Midlife in the United States study. Results indicated that starting levels of income moderated changes in four personality traits. Specifically, income moderated the slopes of openness to experience, extraversion, agreeableness, and neuroticism, such that for high-income individuals, openness to experience, extraversion, and agreeableness were less likely to decline and more likely to either increase or remain stable over time, while neuroticism was less likely to increase and more likely to remain stable over time. Conversely, personality traits were weaker predictors of income change as slopes of income were not moderated by starting levels of any of the personality traits. Moreover, changes in income were not correlated with changes in any of the personality traits. The findings suggest that individual differences in income could potentially explain diverging trajectories of personality change.

Keywords: big five, income, personality development, personality change, socioeconomic status

Women are unhappier than men in anxiety, depression, fearfulness, sadness, loneliness, & anger; are also less satisfied with many aspects of their lives such as democracy, the economy, the state of education and health services

The Female Happiness Paradox. David G. Blanchflower & Alex Bryson. NBER Working Paper 29893.  March 2022. https://www.nber.org/papers/w29893

Abstract: Using data across countries and over time we show that women are unhappier than men in unhappiness and negative affect equations, irrespective of the measure used – anxiety, depression, fearfulness, sadness, loneliness, anger – and they have more days with bad mental health and more restless sleep. Women are also less satisfied with many aspects of their lives such as democracy, the economy, the state of education and health services. They are also less happy in the moment in terms of peace and calm, cheerfulness, feeling active, vigorous, fresh and rested. However, prior evidence on gender differences in global wellbeing metrics – happiness and life satisfaction – is less clear cut. Differences vary over time, location, and with model specification and the inclusion of controls especially marital status. We also show that there are significant variations by month in happiness data regarding whether males are happier than females but find little variation by month in unhappiness data. It matters which months are sampled when measuring positive affect but not with negative affect. These monthly data reveal that women’s happiness was more adversely affected by the COVID shock than men’s, but also that women’s happiness rebounded more quickly suggesting resilience. As a result, we now find strong evidence that males have higher levels of both happiness and life satisfaction in recent years even before the onset of pandemic. As in the past they continue to have lower levels of unhappiness. A detailed analysis of several data files, with various metrics, for the UK confirms that men now are happier than women.

Genetic Link to Fear Memories Found Hiding Within Mice's "Junk DNA"

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3. Wei Wei et al. Cell Reports, Vol 38, Iss 12, Mar 22 2022. https://doi.org/10.1016/j.celrep.2022.110546

Highlights

• Targeted RNA sequencing reveals learning-induced lncRNAs in the adult brain

• ADRAM is critical for the formation of fear extinction memory

• ADRAM coordinates the epigenomic regulation of Nr4a

Summary: Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. Combining these data with cell-type-specific ATAC-seq on neurons that had been selectively activated by fear extinction learning, we find inducible 434 lncRNAs that are derived from enhancer regions in the vicinity of protein-coding genes. In particular, we discover an experience-induced lncRNA we call ADRAM (activity-dependent lncRNA associated with memory) that acts as both a scaffold and a combinatorial guide to recruit the brain-enriched chaperone protein 14-3-3 to the promoter of the memory-associated immediate-early gene Nr4a2 and is required fear extinction memory. This study expands the lexicon of experience-dependent lncRNA activity in the brain and highlights enhancer-derived RNAs (eRNAs) as key players in the epigenomic regulation of gene expression associated with the formation of fear extinction memory.

Discussion

Here, we report the discovery of widespread experience-dependent lncRNA activity in the adult ILPFC, and further reveal a significant number of inducible eRNAs that respond selectively to fear extinction learning. This class of lncRNA was first discovered at scale more than a decade ago by the Greenberg group who identified thousands of sites outside known promoter regions in primary cortical neurons stimulated with KCl in vitro, which exhibited features of enhancer elements, including binding of CBP and the deposition of the histone modification H3K4me1 (

Kim et al., 2010

). Transcriptional activity at these sites showed a positive correlation with downstream mRNA expression, suggesting a context-specific permissive relationship between eRNAs and their proximal mRNA partners. 

Malik et al., 2014

 went on to functionally characterize neuronal enhancers and identify another histone modification, H3K27ac, as a key marker of their active state. An overlay of our lncRNA capture-seq data with learning-induced enhancer signatures in the adult brain (

Halder et al., 2016

), as well as our cell-type-specific ATAC-seq signatures in learning-activated Arc+ neurons, revealed that there are many experience-dependent lncRNAs in the ILPFC that are endowed with features of activity-inducible eRNAs. Notably, all six of the validated eRNA-associated protein-coding gene candidates have been shown to be involved in plasticity, suggesting that this class of lncRNA is, in general, permissively involved in the regulation of experience-dependent gene expression.

One of the most interesting findings of our study beyond the necessary role of ADRAM in fear extinction is that it binds directly to the Nr4a2 promoter; however, in doing so it does not form an R-loop or promote chromosome looping. trans-Acting lncRNAs are known to form triplex structures on double-stranded DNA using a Hoogsteen base-pairing rule in the DNA target (

Li et al., 2016

). These structures are distinct from R-loops and could represent a mechanism by which lncRNAs act in a combinatorial manner to simultaneously serve as both guides and scaffolds. Indeed, examination of the 1 kb upstream promoter sequence of NR4A2 revealed two sites proximal to the TSS, with 25 nucleotide long complementary sequences found within exon III of ADRAM. Notably, these sites overlap with G-quadruplex motifs that are predicted to enable triplex formation. These findings suggest that ADRAM functions as a guide via a direct interaction with the Nr4a2 promoter and may do so via the formation of an RNA:DNA triplex at sites of structural reactivity. Future studies will investigate whether dynamic DNA structure states are the key to how lncRNAs find their genomic targets to regulate gene expression in an experience-dependent manner.

The 14-3-3 family of evolutionarily conserved chaperone proteins is ubiquitously expressed in the brain and highly enriched at the synapse (

Martin et al., 1994

) being involved in a variety of neuronal processes, including synaptic plasticity (

Berg et al., 2003

; 

Marzinke et al., 2013

; 

Foote et al., 2015

). Our discovery of a direct interaction between ADRAM and 14-3-3 extends the capabilities of this class of chaperones to include functional activity as both an RNA-binding protein and a molecule that exerts its influence through protein-protein interactions. This is not without precedent as many proteins are able to interact with RNA, DNA, and other proteins. For example, YY1 interacts with both RNA and DNA, as well as other proteins, to promote its role as a regulator at the Xist locus (

Jeon and Lee, 2011

). Together with the observation that 14-3-3 is involved in learning and memory (

Qiao et al., 2014

), and our demonstration of how 14-3-3 interacts with eRNA to facilitate gene expression in fear extinction, these findings advance our understanding of the functional importance of this class of chaperones in the brain.

Histone modifications at neuronal enhancers also appear to be a requirement for the induction of activity-dependent genes and are particularly important in the case of rapidly induced immediate-early genes (

Chen et al., 2019

). We found a broad overlap with H3K27ac, an open chromatin ATAC signature in activated neurons, and the expression of lncRNAs. Previous work has shown that eRNA activity often precedes, and then drives, the expression of immediate-early genes, such as c-Fos, which occurs via a direct interaction with the histone acetyltransferase domain of CBP (

Carullo et al., 2020

). In addition, a large number of eRNAs have been shown to bind to CBP, correlating with the expression of downstream genes that require CBP for their induction (

Bose and Berger, 2017

). Our data on the functional relationship between ADRAM, HDAC3, HDAC4, CBP, and Nr4a2 agree with these observations and, importantly, extend the findings to include the ILPFC where they are critically involved in fear extinction. Our conclusion is that ADRAM functions as both a guide and a scaffold to epigenomically regulate extinction learning-induced Nr4a2 expression. There are now many examples of multifunctional lncRNAs. For example, in dopaminergic neurons, antisense Uchl1 regulates the expression of Uchl1 in the nucleus and then shuttles to the cytoplasm where it promotes Uchl1 translation (

Carrieri et al., 2012

). Furthermore, owing to its modular domain structure, Neat1 functions in cis to coordinate the deposition of learning-related repressive chromatin modifiers along the genome (

Butler et al., 2019

) and in trans to govern paraspeckle assembly by influencing phase separation (

Yamazaki et al., 2018

).

In summary, the discovery of an lncRNA that is required for fear extinction deepens our understanding of learning-induced epigenomic mechanisms by integrating the modular function of enhancer-derived lncRNAs with key epigenomic processes involved in memory, and answers the long-standing question of how certain HDACs and CBP coordinate to confer their influence on localized gene regulation with a high degree of state-dependent selectivity. LncRNAs therefore provide a bridge to link dynamic environmental signals with epigenomic mechanisms of gene regulation. Together, these findings broaden the scope of experience-dependent lncRNA activity, and underscore the importance of considering eRNAs in the adult cortex as potential therapeutic targets for fear-related neuropsychiatric disorders.

 Limitations of the study

In this work, we identify an enhancer-derived lncRNA that is necessary for the formation of fear extinction memory in male mice. However, an examination of ADRAM and Nr4a2 mRNA expression in the ILPFC after extinction learning in randomly cycling females revealed no increase in ADRAM expression in the female ILPFC. In contrast, Nr4a2 was induced by training in both males and females (Figure S9). These results indicate that, although Nr4a2 may be generally induced by experience in both sexes, it may not be regulated by ADRAM under conditions where successful extinction does not occur. With respect to sex differences in fear extinction, we have also previously found that male and female mice respond differently to the standard extinction protocol used in our laboratory (

Baker-Andresen et al., 2013

) and that the electrophysiological signature in the prelimbic PFC during fear extinction is very different between males and females (

Fenton et al., 2014

, 

Fenton et al., 2016

). Therefore, it is highly plausible that there are female-specific molecular mechanisms that are involved in fear-related learning. Future studies on the role of lncRNAs in fear extinction in females will require the use of a sex-specific learning protocol to reveal brain region-specific molecular mechanisms underlying memory in these mice. In addition, although we have demonstrated that 14-3-3 is a key regulatory protein that interacts with ADRAM, there were other candidates identified by mass spectrometry that have not been validated. At this stage, these data should therefore be considered preliminary until further experiments are carried out. Finally, it is not yet known whether ADRAM is necessary for other forms of learning. 

A decade ago, now-seminal work showed that children are strikingly unskilled at simple tool innovation; since then, a surge of research has replicated these findings across diverse cultures

After a decade of tool innovation, what comes next? Bruce S. Rawlings. Child Development Perspectives, March 24 2022. https://doi.org/10.1111/cdep.12451

Abstract: A decade ago, now-seminal work showed that children are strikingly unskilled at simple tool innovation. Since then, a surge of research has replicated these findings across diverse cultures, which has stimulated evocative yet unanswered questions. Humans are celebrated among the animal kingdom for our proclivity to create and use tools and have the most complex and diverse technology on earth. Our capacity for tool use has altered our ecological environments irrevocably. How can we achieve so much, yet tool innovation be such a difficult and late-developing skill for children? In this article, I briefly summarize what we know about the development of tool innovation, then discuss five outstanding questions in the field. With a focus on different empirical and theoretical perspectives, I argue that addressing these questions is crucial for understanding fully the ontogeny of one of humans’ most notable skills.

DOES FORMAL EDUCATION AFFECT INNOVATION?

In its 2020 Workplace Learning Report, LinkedIn, the global employment company, surveyed professionals in 18 countries, finding that creativity was employees’ most desired soft skill (LinkedIn, 2020). Surveys such as these highlight the increasing demand for innovative and creative skills as valuable economic resources and have motivated global research and educational initiatives exploring whether these skills can be taught in formal education settings (Qian et al., 2019). The impact of formal education on creativity and innovation remains a debated topic. Some argue that the focus of most educational institutions on norm following, rote learning, and standardized teaching and assessments inhibits creative and innovative expression (Goens & Streifer, 2013). Others contend that the experiences afforded by schools, such as wider social interaction, collaboration, and exposure to novel information, promote these skills (Sahlberg, 2009).

To my knowledge, no study has directly assessed the impact of formal education on innovation. However, indirect evidence suggests that exposure to and the quality of formal education may be influential. In one study, 8- to 18-year-olds from the Tsimane population of Amazonian Bolivia who attended high-quality schools outperformed children of the same age and region who went to low-quality schools on abstract reasoning and problem-solving tasks; also, the performance of the children who went to high-quality schools improved significantly more over time (Davis et al., 2021). In developmental studies and research with adults, richer and more diverse social experiences (which attending school presumably promotes) facilitate innovation (Baer et al., 2015; Rawlings, 2018). However, proponents of informal education correctly highlight the cognitive and social benefits of learning outside of school contexts (Sefton-Green, 2012), including how such learning relates to divergent thinking (Dahlman et al., 2013).

These findings are indirect observations, and it is difficult to draw strong conclusions about the relation between formal education and innovation without direct assessments. Given the importance of innovation as a major skill of the 21st century, whether schools can foster the next generation of innovative minds is a topic of global interest. Researchers should examine if and how school curricula, attendance, and academic achievement shape innovation. Even within formal educational settings, approaches to education vary, and work is needed to examine whether specific educational philosophies or activities (e.g., engaging in innovative problem solving, peer collaboration) promote innovation, and whether others (e.g., rote learning, standardized assessments) hinder it. Many schools promote convergent problem solving, focusing on single, correct solutions (e.g., in mathematical problem solving); how does this affect tool innovation? Does informal education shape innovation and if so, how? The globalization of formal education provides a unique and time-sensitive opportunity to document the impact of formal and informal education on the next generation of innovators.

CONCLUSION

Humans’ proclivity to make and use tools is one of our most distinguished skills, allowing us to survive and prosper in diverse and harsh environments. Particularly puzzling, then, is that tool innovation is such a difficult and late-developing skill. Although the field has made significant progress over the past decade, many outstanding questions remain, and using theoretically derived empirical research to answer them will allow us to make significant strides in our understanding of the development of tool innovation. However, doing so will require rigorous planning, and addressing each question posed here presents unique challenges.

Understanding why tool innovation is so difficult for children calls for disentangling the contributions of cognitive, social, and environmental factors through carefully designed experiments. It also requires introspection about the definitions and methods we currently use to assess tool innovation. Conducting cross-cultural work requires striking a balance between control and generalizability across populations, versus implementing culturally appropriate tool innovation measures, to draw fair comparative conclusions.

This is a difficult endeavor that can only be tackled by extensive piloting alongside collaboration with local researchers and community members. Understanding the trajectory of tool innovation abilities beyond childhood necessitates designing tasks and paradigms that ostensibly capture the same skills and processes in children, adolescents, and adults—a feat the field has yet to achieve. Studying how tool innovation transfers across domains will involve establishing a variety of appropriate measures of innovation and creativity, ideally with longitudinal data to document consistency over time. Finally, examining the association between formal education and innovative skills requires collating measures of school quality and educational philosophy, which vary meaningfully across samples as well as within and across nations. If these challenges are overcome, the field will move forward in a way not before seen. 

Professors are generally not seen as highly narcissistic, though they are viewed as more narcissistic than elementary school teachers

Perceptions of narcissism in college professors. Harry M. Wallace, Alejandro Carrillo & Jack Kelley. The Journal of Social Psychology, Mar 20 2022. https://doi.org/10.1080/00224545.2022.2050167

Abstract: We conducted three studies to examine perceptions of grandiose narcissism in college professors. Narcissism might appear incompatible with the profession if professors are viewed fundamentally as helpers or as introverted bookworms. Then again, people might expect professors to display big egos congruent with the prestige of their profession and their privileged public platforms. Our research indicates that professors are generally not seen as highly narcissistic according to the criteria of the Narcissistic Personality Inventory and the Narcissistic Admiration and Rivalry Questionnaire, though they are viewed as more narcissistic than elementary school teachers. More professor narcissism was expected at colleges that prioritize scholarly productivity over teaching excellence. Male professors were viewed as more narcissistic, but only for narcissism dimensions associated with interpersonal hostility and for judgments of whether professors are “narcissistic.” We discuss possible implications for narcissistic professors’ ability to exploit the gap between academic ideals and reward system realities.

Keywords: Narcissismprofessorteachingacademiastereotype

While 'misery loves company' is indeed borne out among certain populations within the sample, we find stronger and more widespread support for the opposite phenomenon, suggesting rather that ‘happiness hates company’

Does misery love company? An experimental investigation. Katherine Farrow, Gilles Grolleau, Lisette Ibanez. Oxford Economic Papers, Volume 74, Issue 2, April 2022, Pages 523–540, https://doi.org/10.1093/oep/gpab011

Abstract: The conventional wisdom summarized in the adage ‘misery loves company’ suggests that suffering can be made easier to bear if it is also shared by others. Given increasing interest in subjective well-being and happiness as constituents of national wealth and priorities in policy-making and organizational management, we empirically investigate the validity of this phenomenon in order to explore whether it may be possible to mitigate decreases in subjective well-being simply by leveraging social comparison. We implement an experimental survey designed to gauge the suitability of this strategy on a representative sample of approximately 2,000 US residents. Our results indicate that, while this hypothesis is indeed borne out among certain populations within the sample, we find stronger and more widespread support for the opposite phenomenon, suggesting rather that ‘happiness hates company’. These novel findings can inform policy interventions aiming to enhance well-being and point to promising avenues for further work.

JEL C90 - GeneralD03 - Behavioral Microeconomics: Underlying PrinciplesD60 - GeneralI31 - General Welfare

People with gender disphoria, particularly male-to-female, want to have children more than cisgenders

Fertility Desire and Motivation Among Individuals with Gender Dysphoria: A Comparative Study. Emre Durcan et al. Journal of Sex & Marital Therapy, Mar 25 2022. https://doi.org/10.1080/0092623X.2022.2053617

Abstract: Despite receiving Gender-Affirming Hormone Therapy or Gender-Affirming Surgery, which may adversely impact their fertility, people with Gender Dysphoria (GD) may desire to form families. In this study, we aimed to quantitatively display fertility desire from the perspective of these individuals, despite all the legal challenges they face. The single center, cross-sectional comparative study included individuals with GD and cisgender volunteers. A Sociodemographic Data Form, the Fertility Desire Data Form, the Childbearing Motivations Scale and the Fertility Desire Scale were used. Of the 414 participants, 171 were individuals with GD (110 FtM; 61 MtF) and 243 were cisgender volunteers (142 cis-males; 101 cis-females). While 22% of the people with GD stated that they had regrets about not undergoing fertility preservation, 16% stated that they would like this process if it were legal. People with GD, particularly MtF, want to have children more than cisgenders. Moreover, people with MtF exhibited less negative motivations toward becoming parents, despite having reservations regarding the socioeconomic aspect of parenthood. Our findings indicate that fertility desire in people with GD is not less in comparison to cisgender people. Healthcare professionals should not forget to offer fertility preservation options as part of clinical practice before Gender-Affirming Therapy.

We stick to our romantic relationships even when we discover "dealbreakers" in a partner that presumably make the person unsuitable as a mate

Dealbreakers, or dealbenders? Capturing the cumulative effects of partner information on mate choice. Samantha Joel, Nicolyn Charlot. Journal of Experimental Social Psychology, Volume 101, July 2022, 104328. https://doi.org/10.1016/j.jesp.2022.104328

Abstract: Entering and establishing a long-term relationship is typically a gradual process, as dating partners acquire information about each other over weeks or months. In contrast, existing mate selection paradigms (e.g., lab experiments, speed-dating) typically examine single brief encounters with real or potential mates. In the current research, we used a Choose Your Own Adventure design to examine how potential dealbreakers operate within the context of a broader relationship dynamic. In two studies, a combined total of 1585 participants read a story about a new dating relationship. At each of 17 junctures in the story, participants chose whether to continue dating or end the relationship. Potential dealbreakers were independently manipulated to be present or absent at each juncture, for a total of up to 17 negative pieces of information about the partner. Study 2 was a preregistered replication and extension of Study 1. On average, participants did not reject the hypothetical partner until several potential dealbreakers had been presented (M = 4.20 in Study 1, M = 3.68 in Study 2). Participants' self-reported dealbreakers consistently aligned with their in-story decisions. Even so, participants tended to encounter at least two of their own personal dealbreakers before choosing to reject (Study 2). Together, these studies highlight the sequential, iterative nature of partner evaluations, and illustrate a novel, accessible method for testing models of early relationship development.

Keywords: Romantic relationshipsMate choiceDealbreakersFledgling relationshipsRelationship developmentCompatibility