Saturday, November 17, 2018

Gene discovery & polygenic prediction from a genome-wide association study in 1.1 million individuals: Explain 11–13% of the variance in educational attainment & 7–10% in cognitive performance

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. James J. Lee et al. Nature Genetics, volume 50, pages1112–1121 (Jul 2018). https://www.nature.com/articles/s41588-018-0147-3

Abstract: Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

Associations & civil society as key factors in a healthy liberal democracy: do individuals who are members of civil associations vote less for populist parties?; & does membership in associations decrease when populist parties are in power?

Populism and Civil Society. Tito Boeri; Prachi Mishra; Chris Papageorgiou; Antonio Spilimbergo. Int'l Monetary Fund, Working Paper No. 18/245, Nov 16, 2018. https://www.imf.org/en/Publications/WP/Issues/2018/11/17/Populism-and-Civil-Society-46324

Summary: Populists claim to be the only legitimate representative of the people. Does it mean that there is no space for civil society? The issue is important because since Tocqueville (1835), associations and civil society have been recognized as a key factor in a healthy liberal democracy. We ask two questions: 1) do individuals who are members of civil associations vote less for populist parties? 2)does membership in associations decrease when populist parties are in power? We answer thesequestions looking at the experiences of Europe, which has a rich civil society tradition, as well as of Latin America, which already has a long history of populists in power. The main findings are that individuals belonging to associations are less likely by 2.4 to 4.2 percent to vote for populist parties, which is large considering that the average vote share for populist parties is from 10 to 15 percent. The effect is strong particularly after the global financial crisis, with the important caveat that membership in trade unions has unclear effects.

Active-sampling policies & their relation to attention & curiosity: Sampling & search depend on individual preferences over cognitive states, including attitudes towards uncertainty, learning progress & types of information

Towards a neuroscience of active sampling and curiosity. Jacqueline Gottlieb & Pierre-Yves Oudeyer. Nature Reviews Neuroscience, volume 19, pages758–770 (2018), https://www.nature.com/articles/s41583-018-0078-0

Abstract: In natural behaviour, animals actively interrogate their environments using endogenously generated ‘question-and-answer’ strategies. However, in laboratory settings participants typically engage with externally imposed stimuli and tasks, and the mechanisms of active sampling remain poorly understood. We review a nascent neuroscientific literature that examines active-sampling policies and their relation to attention and curiosity. We distinguish between information sampling, in which organisms reduce uncertainty relevant to a familiar task, and information search, in which they investigate in an open-ended fashion to discover new tasks. We review evidence that both sampling and search depend on individual preferences over cognitive states, including attitudes towards uncertainty, learning progress and types of information. We propose that, although these preferences are non-instrumental and can on occasion interfere with external goals, they are important heuristics that allow organisms to cope with the high complexity of both sampling and search, and generate curiosity-driven investigations in large, open environments in which rewards are sparse and ex ante unknown.

Generational changes in personality & frequencies of individual words 1900-2002: Modest increase for Extraversion-, Agreeableness-, and Stability-related adjectives; Intellect-related words increased up to 1960, then declined

Generational Changes in Personality: The Evidence From Corpus Linguistics. Eka Roivainen. Psychological Reports, https://doi.org/10.1177/0033294118805937

Abstract: According to theory, social change is interconnected with changes in mental phenomena and language. In the present study, secular change in the usage frequencies of common English personality adjectives (n = 336) qualifying the word person was analyzed over the period 1900 to 2002. It was hypothesized that words that represent those personality traits that are advantageous in occupations typical for modern societies have increased in frequency. The results show changes in the frequencies of individual words but stability across the five major categories of trait adjectives in the Google Books English fiction corpus. A modest increase for Extraversion-, Agreeableness-, and Stability-related adjectives was observed in the Google Books English 2012 corpus. Frequency of Intellect-related words increased up to 1960 and then declined. The results suggest that (a) human nature has changed little over the 20th century, (b) generational changes in personality are not strongly reflected in language, or (c) the corpus linguistic method used is not reliable for studying generational changes in personality.

Keywords: Personality, generational change, Google Ngram, corpus linguistics, societal change

I’m not the person I used to be: Bad actions that happened further in the past are more morally wrong than those that happened more recently

Stanley, M. L., Henne, P., Iyengar, V., Sinnott-Armstrong, W., & De Brigard, F. (2017). I’m not the person I used to be: The self and autobiographical memories of immoral actions. Journal of Experimental Psychology: General, 146(6), 884-895. http://dx.doi.org/10.1037/xge0000317

Abstract: People maintain a positive identity in at least two ways: They evaluate themselves more favorably than other people, and they judge themselves to be better now than they were in the past. Both strategies rely on autobiographical memories. The authors investigate the role of autobiographical memories of lying and emotional harm in maintaining a positive identity. For memories of lying to or emotionally harming others, participants judge their own actions as less morally wrong and less negative than those in which other people lied to or emotionally harmed them. Furthermore, people judge those actions that happened further in the past to be more morally wrong than those that happened more recently. Finally, for periods of the past when they believed that they were very different people than they are now, participants judge their actions to be more morally wrong and more negative than those actions from periods of their pasts when they believed that they were very similar to who they are now. The authors discuss these findings in relation to theories about the function of autobiographical memory and moral cognition in constructing and perceiving the self over time.


Check also The neural correlates of moral decision-making: A systematic review and meta-analysis of moral evaluations and response decision judgements. Beverley Garrigan, Anna L.R. Adlam, Peter E. Langdon. Brain and Cognition, Volume 108, October 2016, Pages 88-97. https://doi.org/10.1016/j.bandc.2016.07.007
Corrigendum to “The neural correlates of moral decision-making: A systematic review and meta-analysis of moral evaluations and response decision judgements” in Brain and Cognition, Volume 111, February 2017, Pages 104-106

Highlights
•    We compared brain activation when making your own moral decision or when evaluating another’s decision.
•    We included 28 experiments and used activation likelihood estimate analysis.
•    The left middle temporal gyrus, cingulate gyrus, and medial frontal gyrus was active for both types of decisions.
•    Making your own decision also activated the left and right middle temporal gyrus and the right precuneus.
•    Making a decision about yourself involves additional brain areas.

Abstract: The aims of this systematic review were to determine: (a) which brain areas are consistently more active when making (i) moral response decisions, defined as choosing a response to a moral dilemma, or deciding whether to accept a proposed solution, or (ii) moral evaluations, defined as judging the appropriateness of another’s actions in a moral dilemma, rating moral statements as right or wrong, or identifying important moral issues; and (b) shared and significantly different activation patterns for these two types of moral judgements. A systematic search of the literature returned 28 experiments. Activation likelihood estimate analysis identified the brain areas commonly more active for moral response decisions and for moral evaluations. Conjunction analysis revealed shared activation for both types of moral judgement in the left middle temporal gyrus, cingulate gyrus, and medial frontal gyrus. Contrast analyses found no significant clusters of increased activation for the moral evaluations-moral response decisions contrast, but found that moral response decisions additionally activated the left and right middle temporal gyrus and the right precuneus. Making one’s own moral decisions involves different brain areas compared to judging the moral actions of others, implying that these judgements may involve different processes.

Arguably this is causal evidence that teacher expectations affect students' educational attainment

Teacher Expectations Matter. Nicholas W. Papageorge, Seth Gershenson, Kyung Min Kang. NBER Working Paper No. 25255, Nov 2018. https://www.nber.org/papers/w25255

Abstract: We develop and estimate a joint model of the education and teacher-expectation production functions that identifies both the distribution of biases in teacher expectations and the impact of those biases on student outcomes via self-fulfilling prophecies. Our approach leverages a unique feature of a nationally representative dataset: two teachers provided their educational expectations for each student. Identification of causal effects exploits teacher disagreements about the same student, an idea we formalize using lessons from the measurement error literature. We provide novel, arguably causal evidence that teacher expectations affect students' educational attainment: Estimates suggest an elasticity of college completion with respect to teachers' expectations of about 0.12. On average, teachers are overly optimistic about students' ability to complete a four-year college degree. However, the degree of over-optimism of white teachers is significantly larger for white students than for black students. This highlights a nuance that is frequently overlooked in discussions of biased beliefs: less biased (i.e., more accurate) beliefs can be counterproductive if there are positive returns to optimism or if there are socio-demographic gaps in the degree of teachers' optimism; we find evidence of both.