Saturday, August 3, 2019

Techniques have been identified that can modify memories at both stages of initial storage and re-storage, but implementation into clinical therapies has produced inconsistent benefits

Memory editing from science fiction to clinical practice. Elizabeth A. Phelps & Stefan G. Hofmann. Nature, volume 572, pages 43–50 (2019). July 31 2019, https://www.nature.com/articles/s41586-019-1433-7

Abstract: Science fiction notions of altering problematic memories are starting to become reality as techniques emerge through which unique memories can be edited. Here we review memory-editing research with a focus on improving the treatment of psychopathology. Studies highlight two windows of memory vulnerability: initial storage, or consolidation; and re-storage after retrieval, or reconsolidation. Techniques have been identified that can modify memories at each stage, but translating these methods from animal models to humans has been challenging and implementation into clinical therapies has produced inconsistent benefits. The science of memory editing is more complicated and nuanced than fiction, but its rapid development holds promise for future applications.

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